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Mikecz, Katalin
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overview My research focuses on rheumatoid arthritis (RA), a joint disease that causes chronic pain and disability. We described a new mouse model of RA 30 years ago, and fully characterized it with respect to its pathogenesis, immunology, and genetics. My group was the first to report on the non-invasive imaging of the trafficking of white blood cells in the inflamed joints of live mice (with RA-like arthritis) using two-photon microscopy. My current research interest is in the immune recognition of a cartilage molecule termed proteoglycan (or aggrecan) by lymphocytes from mice with arthritis and from RA patients. Our ultimate goals are to identify therapeutic targets and to find a cure for RA. My ORCID is 0000-0003-1506-4296 My Scopus ID is 7006756303 My NIH COMMONS name is KMIKECZ Education: MD: Medical University of Debrecen, Hungary (1982) PhD: Medical University of Debrecen & Hungarian Academy of Sciences, Budapest, Hungary (1989)
One or more keywords matched the following items that are connected to Mikecz, Katalin
Item TypeName
Concept Arthritis, Rheumatoid
Academic Article Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14.
Academic Article Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption.
Academic Article Proteoglycan-specific autoreactive antibodies and T-lymphocytes in experimental arthritis and human rheumatoid joint diseases.
Academic Article Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology.
Academic Article Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis.
Academic Article Interferon-gamma but not granulocyte/macrophage colony-stimulating factor augments proteoglycan presentation by synovial cells and chondrocytes to an autopathogenic T cell hybridoma.
Academic Article The role of adhesion molecules in the development of autoimmune arthritis.
Academic Article Mediators and autopathogenic effector cells in proteoglycan-induced arthritic and clinically asymptomatic BALB/c mice.
Academic Article CD44 expression by leucocytes in rheumatoid arthritis and modulation by specific antibody: implications for lymphocyte adhesion to endothelial cells and synoviocytes in vitro.
Academic Article Progressive polyarthritis induced in BALB/c mice by aggrecan from normal and osteoarthritic human cartilage.
Academic Article Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis.
Academic Article Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis.
Academic Article A genome scan using a novel genetic cross identifies new susceptibility loci and traits in a mouse model of rheumatoid arthritis.
Academic Article Vitaxin applied molecular evolution.
Academic Article Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis.
Academic Article Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice.
Academic Article Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis.
Academic Article Proteoglycan-induced arthritis: immune regulation, cellular mechanisms, and genetics.
Academic Article Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis.
Academic Article Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid arthritis.
Academic Article Visualization and in situ analysis of leukocyte trafficking into the ankle joint in a systemic murine model of rheumatoid arthritis.
Academic Article Expression of CD44 and L-selectin in the innate immune system is required for severe joint inflammation in the proteoglycan-induced murine model of rheumatoid arthritis.
Academic Article Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis.
Academic Article Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation.
Academic Article Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis.
Academic Article IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis.
Academic Article Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints.
Academic Article Impaired activation-induced cell death promotes spontaneous arthritis in antigen (cartilage proteoglycan)-specific T cell receptor-transgenic mice.
Academic Article Osteoarthritis-like damage of cartilage in the temporomandibular joints in mice with autoimmune inflammatory arthritis.
Academic Article Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis.
Academic Article Suppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis.
Academic Article Arthritogenic T cells drive the recovery of autoantibody-producing B cell homeostasis and the adoptive transfer of arthritis in SCID mice.
Academic Article In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis.
Academic Article Non-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models.
Academic Article Genetics of rheumatoid arthritis - a comprehensive review.
Academic Article Pharmacogenetics and pharmacogenomics in rheumatology.
Academic Article The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis.
Academic Article Differentially expressed epigenome modifiers, including aurora kinases A and B, in immune cells in rheumatoid arthritis in humans and mouse models.
Academic Article Of mice and men: how animal models advance our understanding of T-cell function in RA.
Academic Article Epigenetics in the pathogenesis of rheumatoid arthritis.
Academic Article Proteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritis.
Academic Article Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study.
Academic Article Suppression of proteoglycan-induced autoimmune arthritis by myeloid-derived suppressor cells generated in vitro from murine bone marrow.
Academic Article Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis.
Academic Article Enigma of IL-17 and Th17 Cells in Rheumatoid Arthritis and in Autoimmune Animal Models of Arthritis.
Academic Article Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage.
Academic Article Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis.
Academic Article An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis.
Academic Article Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis.
Academic Article Amelioration of Autoimmune Arthritis in Mice Treated With the DNA Methyltransferase Inhibitor 5'-Azacytidine.
Academic Article Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase.
Academic Article Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis.
Academic Article Restoring the Balance between Pro-Inflammatory and Anti-Inflammatory Cytokines in the Treatment of Rheumatoid Arthritis: New Insights from Animal Models.
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  • Arthritis Rheumatoid